White matter hyperintensities (WMH) seen on T2WI are a hallmark of multiple sclerosis (MS) as it indicates inflammation\nassociated with the disease. Automatic detection of the WMH can be valuable in diagnosing and monitoring of treatment\neffectiveness. T2 fluid attenuated inversion recovery (FLAIR) MR images provided good contrast between the lesions and other\ntissue; however the signal intensity of gray matter tissue was close to the lesions in FLAIR images that may cause more false positives\nin the segment result. We developed and evaluated a tool for automated WMH detection only using high resolution 3D T2 fluid\nattenuated inversion recovery (FLAIR) MR images.We use a high spatial frequency suppression method to reduce the gray matter\narea signal intensity.We evaluate our method in 26MS patients and 26 age matched health controls. The data from the automated\nalgorithm showed good agreement with that from the manual segmentation.The linear correlation between these two approaches\nin comparing WMH volumes was found to be Y = 1.04X + 1.74 (R2 = 0.96). The automated algorithm estimates the number,\nvolume, and category of WMH.
Loading....